王洪巖，1989年出生，中國水產科學研究院黃海水產研究所助理研究員，2019年獲武漢大學生物化學與分子生物學博士學位。主要研究方向：利用基因組學、單細胞轉錄組學和表觀遺傳組學等高通量技術手段，聚焦海水養殖物種免疫系統構成和抗病抗逆的分子機制研究，探索免疫系統的功能演化，發掘新的免疫防御機制，并研究免疫與生長和代謝之間的關系。承擔國家自然科學基金項目1項，山東省博士后創新項目資助1項。目前在Science Advances，Cell Host & Microbe等雜志發表論文10余篇，其中第一作者2篇。
代表性論文
1. Li W,Wang HY, Zhao X, Duan H, Cheng B, Liu Y, Zhao M, Shu W, Mei Y, Wen Z, Tang M, Guo L, Li G, Chen Q, Liu X, Du HN. A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair.Sci Adv. 2019 Mar 6;5(3):eaau7566.
2. Wang HY, Li Y, Xue T, Cheng N, Du HN. Construction of a series of pCS2+ backbone-based Gateway vectors for overexpressing various tagged proteins in vertebrates.Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1128-1134.
3. Liu X, Huang Y, Tan F,Wang HY, Chen JY, Zhang X, Zhao X, Liu K, Wang Q, Liu S, Piferrer F, Fan G, Shao C. Single-Cell Atlas of the Chinese Tongue Sole (Cynoglossus semilaevis) Ovary Reveals Transcriptional Programs of Oogenesis in Fish.Front Cell Dev Biol. 2022 Mar 1;10:828124.
4. Lu YF, Liu Q, Liu KQ,Wang HY, Li CH, Wang Q, Shao CW. Identification of global alternative splicing and sex-specific splicing via comparative transcriptome analysis of gonads of Chinese tongue sole (Cynoglossus semilaevis).Zool Res. 2022 May 18;43(3):319-330.
5. Lu B, Ren Y, Sun X, Han C,Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B, Huang Z. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3.Cell Host Microbe. 2017 Jul 12;22(1):86-98.e4.
6. Li WZ,Wang HY, Du HN. Research Progress on Non-histone Protein Methylation.Progress in Biochemistry and Biophysics. 2015, 42(11): 1015-1025.
